Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications
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چکیده
منابع مشابه
Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs
BACKGROUND Stilbene-based compounds show antitumoral, antioxidant, antihistaminic, anti-inflammatory and antimicrobial activities. Here, we evaluated the effect of the trans-resveratrol analogs, pterostilbene, piceatannol, polydatin and oxyresveratrol, against Leishmania amazonensis. METHODOLOGY/PRINCIPAL FINDINGS Our results demonstrated a low murine macrophage cytotoxicity of all four analo...
متن کاملResveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications
BACKGROUND Excessive generation of radical oxygen species (ROS) is a contributor to skin pathologies. Resveratrol (RSV) is a potent antioxidant. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) can ensure close contact and increase the amount of drug absorbed into the skin. In this study, RSV was loaded into SLN and NLC for dermal applications. METHODS Nanoparticles wer...
متن کاملIn vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide.
Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested that the kinetics of preformed and in vivo-formed metabolites are comparable. This subject has been a topic of debate. We have compared the kinetics of in vivo-formed with preformed metabolites. trans-3,5,4'-Trihydroxystilbene [trans-resveratrol (RES)] and its two major metabolites, resvera...
متن کاملOptimization of trans-Resveratrol bioavailability for human therapy.
We have developed an innovative soluble galenic form to overcome the low absorption of trans-Resveratrol (t-Res) as a dry powder. We present here data on pharmacokinetics, bioavailability, and toxicity of t-Res in human volunteers treated with this soluble form, plus additional data on biological effects in rodents. Fifteen healthy volunteers of both sexes received 40 mg of t-Res in two forms, ...
متن کاملmethod validation for the one-month stability study of trans–resveratrol in human plasma
conclusions in lighting conditions, most of t-res was isomerized to the other isomer cis-resveratrol. t-res is unstable in alkali ph and when exposed to light. t-res was quite stable at other conditions, and several freeze-thaw cycles did not have any effect on its stability. results our findings revealed that t-res was quite stable in different temperatures ranging from -70 °c to 25 °c, and ac...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2017
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370217723628